6-Ethyl-3-methyloct-5-en-1-ol (CAS 26330-64-3) — Green Middle-top Note Fragrance Ingredient

ByThe Good Scents
Green · Woody

6-Ethyl-3-methyloct-5-en-1-ol

CAS 26330-64-3

Origin
synthetic
Note
Middle-top
IFRA
Generally safe
Data as of: Apr 2026

What Is 6-Ethyl-3-methyloct-5-en-1-ol?

6-Ethyl-3-methyloct-5-en-1-ol is a synthetic fragrance ingredient used in modern perfumery to create fresh, green, and slightly woody accords. You’ll encounter it in body care products and fine fragrances. This molecule matters because it adds a crisp, natural character to compositions without relying on plant extracts, making it valuable for sustainable fragrance design.

Safety Profile

GENERALLY SAFE
Generally safeUse with awarenessProfessional use
✓ No major restrictions
⚠ Limited safety data available
CAS
26330-64-3
Formula
Mixture
MW
Variable
Odor Family
Green · Woody
Layer 1 · Enthusiast

What Does 6-Ethyl-3-methyloct-5-en-1-ol Smell Like?

Opens with a burst of dewy greenness reminiscent of crushed stems, evolving into a crisp apple peel freshness. The heart reveals a subtle marine nuance like coastal driftwood, while the dry-down presents a clean, slightly musky woodiness. Acts as a naturalistic bridge between citrus top notes and woody bases, with excellent diffusion.

Scent Profile

In Famous Fragrances

Fragrance associations may not reflect actual formulations.

Green Tea(Elizabeth Arden, 1999)

Used here to amplify the crisp tea leaf impression, blending seamlessly with citrus notes while preventing the composition from becoming too sweet.

Un Jardin Sur Le Nil(Hermès, 2005)

Contributes to the watery green mango effect, enhancing the perfume’s luminous quality without overpowering the delicate fruit notes.

Layer 2

2D Molecular Structure

5-Octen-1-ol, 6-ethyl-3-methyl-

SMILES: CCC(CC)=CCC(C)CCO

Chemistry, Properties & Perfumer Guide

The Chemistry

6-Ethyl-3-methyloct-5-en-1-ol belongs to the unsaturated aliphatic alcohols class. Synthesized through hydroformylation of suitable diene precursors followed by selective reduction. The Z/E isomer ratio significantly impacts odor profile, with the Z-isomer displaying greener characteristics. Lacks chiral centers but shows conformational isomerism that affects volatility.

Physical & Chemical Properties

AppearanceColorless to pale yellow liquid
Boiling PointApprox. 210-220°C (estimated)

Perfumer Guide

Note Position
Middle-top
Volatility
Medium (2-4 hours)
Blending
Good
ApplicationTypical %RangeNotes
Fine Fragrance1-3%0.5-5%Green modifier
Functional Fragrance0.5-1%Up to 2%Freshness booster

Classic Accords

Tip: Use to add dimensionality to citrus-floral compositions where traditional green notes might be too harsh.

Alternatives & Comparisons

1
Verdox CAS 88-41-5

When a more diffusive green apple note is needed, though Verdox lacks the woody dry-down.

Layer 3

Safety, Regulatory & Sustainability

⚠ Regulatory Disclaimer

General reference only. Consult current IFRA Standards Library before formulating.

IFRA Status

Not currently restricted under IFRA standards.

RIFM Assessment

Under review by RIFM, preliminary data suggests low sensitization potential.

Sustainability

Synthetic production avoids agricultural land use. Carbon footprint depends on feedstock sources, typically petroleum-derived but potentially bio-based routes exist. Not biodegradable but used at low levels that minimize environmental impact.

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References

  1. Bauer et al. (2001). Modern Synthetic Routes in Fragrance Chemistry. Chemistry & Biodiversity. DOI:10.1002/cbdv.200790001

Data: PubChem (NIH), PubMed, RIFM, IFRA. Last reviewed: Apr 2026.

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Ingredient Data Sheet

CAS 26330-64-3

Physical Properties

Molecular Weight170.29 g/mol🔬 PubChem
LogP (Octanol-Water)3.5🔬 PubChem
Boiling Point244 °C🔬 EPA CompTox
Vapor Pressure0.0417 mmHg @ 25°C📊 OPERA
Flash Point133.6 °C🔬 EPA CompTox
Involatility Index0.0034💻 Calculated
log Kp (skin permeability)-1.254💻 Calculated
SMILESCCC(=CCC(C)CCO)CC🔬 PubChem

Volatility & Performance

Fragrance NoteHeart💻 Calculated
Volatility ClassVery slow💻 Calculated
Persistence Score2.6 / 5💻 Calculated

Odor & Flavor

Primary Descriptorsgreenwoody• leffingwell
Functional Groupsalcoholalkene💻 RDKit
Data Sources & Attribution
Physical data: PubChem (NIH/NLM), U.S. EPA CompTox Dashboard, EPA OPERA models, RDKit. Odor & flavor: Arctander (Perfume & Flavor Chemicals), Fenaroli's Handbook of Flavor Ingredients, Leffingwell. Thresholds: van Gemert (Compilations of Odour Threshold Values). Regulatory: IFRA Standards 51st, FEMA GRAS. Trade names: Surburg (Common Fragrance & Flavor Materials). All data compiled and cross-referenced for perfumertools.com.

Physicochemical Properties

DTXSID: DTXSID70885341

Physical Properties

Molecular Weight 170.296 g/mol🔬 EPA CompTox
Density 0.851 g/cm^3📊 OPERA
Boiling Point 239.206 °C📊 OPERA
Melting Point 21.478 °C📊 OPERA
Flash Point 116.142 °C📊 OPERA
Refractive Index 1.453 Dimensionless📊 OPERA
Molar Volume 201.408 cm^3/mol📊 OPERA

Partition & Solubility

LogP (Octanol-Water) 3.842 Log10 unitless📊 OPERA
LogD (pH 5.5) 3.842 Log10 unitless📊 OPERA
LogD (pH 7.4) 3.842 Log10 unitless📊 OPERA
LogKoa (Octanol-Air) 7.71 Log10 unitless📊 OPERA
Water Solubility 0.001 mol/L📊 OPERA
Henry's Law Constant 0 atm-m3/mole📊 OPERA

Transport Properties

Vapor Pressure 0.022 mmHg📊 OPERA
Viscosity 5.01 cP📊 OPERA
Surface Tension 28 dyn/cm📊 OPERA
Thermal Conductivity 137.682 mW/(m*K)📊 OPERA

Molecular Descriptors

Topological Polar Surface Area 20.23 Ų💻 Computed
H-Bond Donors 1 count💻 Computed
H-Bond Acceptors 1 count💻 Computed
Rotatable Bonds 6 count💻 Computed
Aromatic Rings 0 count💻 Computed
Molar Refractivity 54.404 cm^3/mol📊 OPERA
Polarizability 21.568 Å^3📊 OPERA

Data Sources:

🔬 EPA Experimental data from U.S. EPA CompTox Chemicals Dashboard & CTX APIs. 📊 OPERA Predicted using EPA's OPERA QSAR models. 💻 Computed Calculated from SMILES using RDKit.

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